Orexin A Peptide Vial

Orexin A Peptide Vial is a high-purity neuropeptide available at Direct Anti Peptide, manufactured to ≥98% purity and verified by HPLC and mass spectrometry. This product is supplied exclusively as a laboratory research reagent. For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications.

Product Overview

Orexin A is a 33-amino acid neuropeptide synthesized in the lateral hypothalamus and involved in a broad spectrum of neurophysiological regulatory functions. First identified in the late 1990s, Orexin A (also referred to as Hypocretin-1) is one of two orexin peptides — alongside Orexin B — that act on orexin receptors OX1R and OX2R. Its role in modulating wakefulness, arousal, appetite, and energy homeostasis has made it a compelling molecule for neuroscience, sleep biology, and metabolic research. Direct Anti Peptide supplies this peptide in a pharmaceutical-grade lyophilized format, ready for qualified laboratory use.

Peptide Structure & Amino Acid Sequence

Orexin A is a 33-amino acid peptide with the sequence: QPLPDCCRQKTCSCRLYELLHGAGNHAAGILTL. It contains two intrachain disulfide bonds between cysteine residues at positions 6–12 and 7–14, which are critical to its three-dimensional conformation and receptor-binding activity. The molecular formula is C₁₅₂H₂₄₃N₄₅O₄₄S₄, with a molecular weight of approximately 3,561.1 Da. This unique structural architecture distinguishes Orexin A from Orexin B and underpins its dual receptor affinity, making it a valuable research tool for receptor selectivity studies.

Chemical & Physical Characteristics

• Peptide Name: Orexin A (Hypocretin-1)
• Amino Acid Length: 33 residues
• Molecular Weight: ~3,561.1 Da
• Molecular Formula: C₁₅₂H₂₄₃N₄₅O₄₄S₄
• Appearance: White to off-white lyophilized powder
• Solubility: Soluble in aqueous buffer systems (laboratory grade)
• Purity: ≥98% by HPLC
• Storage Temperature: −20°C (long-term); 4°C (short-term, once reconstituted)

Purity & Analytical Verification (HPLC & MS)

Every batch of Orexin A Peptide Vial supplied by Direct Anti Peptide undergoes rigorous analytical testing prior to release. High-performance liquid chromatography (HPLC) is used to confirm purity at ≥98%, ensuring that each vial contains a highly homogeneous peptide product with minimal impurities or truncated sequences. Mass spectrometry (MS) analysis is performed to verify the correct molecular weight, confirming the structural integrity of the disulfide bonds and full amino acid sequence. A certificate of analysis (CoA) is available upon request for all batch-specific quality data.

Quality Control & Lyophilization Integrity

Orexin A is lyophilized under controlled conditions using validated freeze-drying protocols that preserve peptide stability, bioactivity, and structural integrity over extended storage periods. Each vial is sealed under inert gas and inspected for visual appearance, moisture content, and sterility of the container closure system. The lyophilization process removes residual water to levels that minimize degradation pathways, ensuring that researchers receive a product that performs consistently across experimental conditions. Direct Anti Peptide maintains strict batch traceability throughout the manufacturing and fulfillment chain.

Safety, Handling & Laboratory Precautions

Orexin A Peptide Vial is intended for use by trained laboratory professionals only. Standard biosafety protocols must be followed when handling this material. Researchers should wear appropriate personal protective equipment (PPE), including gloves, laboratory coats, and eye protection. Avoid inhalation of lyophilized powder. This compound must not be administered to humans or animals under any circumstances. Dispose of all waste materials in accordance with local institutional and regulatory guidelines for research biochemicals.

Reconstitution, Packaging & Storage

Orexin A Peptide Vial is supplied in a sealed, sterile glass vial containing lyophilized peptide. For laboratory reconstitution, researchers should refer to peer-reviewed protocols appropriate for their specific assay requirements. Reconstitution should be performed using research-grade solvents appropriate for the intended experimental system. Store the lyophilized product at −20°C, protected from light and moisture. Once reconstituted, aliquot and store at −80°C to minimize freeze-thaw degradation. Avoid repeated freeze-thaw cycles to maintain peptide integrity.

Intended Research Use & Market Positioning

Orexin A is an important subject of study across multiple disciplines including neuroscience, sleep medicine research, metabolic biology, and psychiatry research. Its dual-receptor binding profile and involvement in sleep-wake regulation, appetite control, and reward circuitry make it a highly versatile research peptide. Scientists studying narcolepsy models, energy balance mechanisms, or hypothalamic signaling pathways will find this peptide particularly relevant. Direct Anti Peptide positions this product as a best-in-class research reagent for institutions and independent researchers seeking reliable, competitively priced neuropeptides.

Ordering, Availability & Fulfillment

Direct Anti Peptide offers Orexin A Peptide Vial for sale online with straightforward ordering, competitive pricing, and prompt dispatch. All orders are processed through a secure checkout system and fulfilled with appropriate cold-chain packaging to preserve peptide integrity during transit. Our team is available to assist with bulk order inquiries, institutional purchasing, and documentation requests including CoA and safety data sheets. Order now and benefit from our commitment to quality, transparency, and research-grade standards.

Legal & Regulatory Disclaimer

For research use only. Not for human or veterinary use. Not for clinical, diagnostic, or consumptive applications. Orexin A Peptide Vial is sold exclusively as a laboratory research reagent. Direct Anti Peptide makes no claims regarding the therapeutic, diagnostic, or prophylactic efficacy of this product. Purchasers are solely responsible for ensuring compliance with all applicable local, national, and international laws governing the purchase, handling, and use of research peptides. This product must not be used in any manner inconsistent with its labeling or outside the scope of qualified scientific research.